Beilstein J. Org. Chem.2016,12, 1434–1439, doi:10.3762/bjoc.12.138
mutagenicitytest; quaternary ammonium salt; Introduction
Carbohydrates and alditols occur broadly in nature and possess many biological functions essential to living organisms. Sugars not only contribute as energetic substances, but also serve as building materials for fungi, microbes, plants, and animals
using two different techniques: The Vibrio harveyi luminescence assay and the Ames test. The obtained results support previous findings contesting QAS safety and indicate that QAS, specifically pyridinium derivatives, might be mutagenic.
Keywords: 6-bromohexyl D-glucopyranoside; microbiological
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Graphical Abstract
Scheme 1:
Reagents and conditions; I: HO(CH2)6Br, BF3·Et2O/CH2Cl2, 1 h 0 °C → 3 h, rt, ([32] compound 2 36% yield...